Алексей Сазанов » Публикация
Опубликовано
2005-01-10
Опубликовано на SciPeople2009-08-02 18:06:21
ЖурналNature. 1999. V. 402. P. 411-413.
The dynamics of chromosome evolution in birds and mammals
Аннотация
Comparative mapping, which compares the location of homo-
logous genes in different species, is a powerful tool for studying
genome evolution1. Comparative maps suggest that rates of
chromosomal change in mammals can vary from one to ten
rearrangements per million years1–4. On the basis of these rates
we would expect 84 to 600 conserved segments in a chicken
comparison with human or mouse. Here we build comparative
maps between these species and estimate that numbers of con-
served segments are in the lower part of this range. We conclude
that the organization of the human genome is closer to that of the
chicken than the mouse and by adding comparative mapping
results from a range of vertebrates, we identify three possible
phases of chromosome evolution. The relative stability of
genomes such as those of the chicken and human will enable
the reconstruction of maps of ancestral vertebrates.
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