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Опубликовано 2000-03-12 Опубликовано на SciPeople2009-12-13 04:19:18 ЖурналБиоорганическая химия

Синтез эфиров тритерпеноидов группы лупана и их гепатопротекторная активность.

Флехтер О.Б., Карачурина Л.Т., Поройков В.В., Нигматуллина Л.Р., Балтина Л.А., Зарудий Ф.С., Давыдова В.А., Спирихин Л.В., Байкова И.П., Галин Ф.З., Толстиков Г.А. / Vladimir Poroikov

Биоорганическая химия, 2000, 26 (3), 215-223.

Аннотация Hemisuccinates, hemiphthalates, acetylsalicylates, cinnamates, and p-methoxycinnamates of lupeol, betulin, and 3-O-acetylbetulin were synthesized via interaction with corresponding acid anhydrides or acid chlorides. A number of betulin esters in position 3 and 28 were shown to exhibit a pronounced hepatoprotective effect similar to that of betulin and silibor. These experimental data were in a good agreement with the computer prediction of their biological activity. Betulin 3,28-bishemiphthalate was more effective than carsil in models of experimental hepatitis caused by carbon tetrachloride, tetracycline, and ethanol.