This book describes examples of the use of microbial technologies for the preparation of artemisinins derivatives. Some examples of the formation of various metabolites depending on the composition of the nutrient medium are considered. The production of new artemisinins derivatives with...

Монография посвящена микробиологическим методам получения органических соединений из ряда азотистых гетероциклов (азааренов, хинолонов и насыщенных азотистых...

The monography describes microbial technologies for obtaining of derivatives from a series of nitrogen heterocycles (saturated nitrogen heterocycles, azaarenes and quinolones). It is proposed alternative ways for synthesize substances that are difficult to obtain by the methods of organic...

The monograph describes microbial technologies for obtaining of derivatives of terpenoids. Obtaining new derivatives of terpenoids, including artemisinin derivatives with increased antimalarial activity, is an important goal of research in microbial biotechnology and medicinal chemistry.

In the process of degradation of 4-methylpyridine by bacterium Аrthrobacter sp. KM-4MP were isolated two metabolites and identified as 4-methylpyridin-2-ol and 8-hydroxy-4-methylidene-1H-cyclopenta[1,2-b:3,4-c']dipyridine-2,3,5,7(4H,6H)-tetrone.

The monograph describes examples of the application of microbial technology for obtaining of derivatives of terpenoids. Obtaining new derivatives of terpenoids, including artemisinin derivatives with increased antimalarial activity, is an important goal of research in microbial biotechnology and...

Steroids are derivatives of the triterpenoid squalene, containing three fused cyclohexane rings and a cyclopentane ring, and flavonoids are derivatives of L-phenylalanine, containing two aromatic rings joined by a three-carbon bridge that may form part of a heterocyclic ring. A great variety of...

Монография описывает примеры применения микробных технологий для получения производных из серии азотсодержащих гетероциклов (насыщенных азотсодержащих...

Aspergillus niger is a well-known fungus that has been used for many different biotransformations of organic compounds. The terpenoids include a large variety of natural hydrocarbons and their derivatives, mostly obtained from plant essential oils, but some obtained from animals or fungi. They...

During of growing of cultures of Arthrobacter sp. KM-P in the medium with concentration 2.5 g/L of pyridine it was fully utilized in 24 hours. It was shown the stability of the process of biodegradation of pyridine with immobilized cells for three consecutive periodic processes. Strain...

Probiotics are currently added to a variety of functional foods to provide health benefits to the host and are commonly used by patients with gastrointestinal complaints or diseases. The therapeutic effects of lapachol continue to inspire studies to obtain derivatives with improved bioactivity...

Optically active 2-(4-hydroxyphenylcarbamoyloxymethyl)-1-methyl-1,2,5,6-tetrahydropyridine is obtained on microbiological transformation of 1-methyl-2-(N-phenyl-carbamoyloxymethyl)-1,2,5,6-tetrahydropyridine with a growing culture of the fungus C. verticillata VKPM F-430. Transformation of...

The saturated nitrogen-containing heterocyclic compounds include many drugs and compounds that may be used as synthons for the synthesis of other pharmacologically active substances. The need for new derivatives of saturated nitrogen-containing heterocycles for organic synthesis, biotechnology...

После длительного воздействия пиридина и его производных на образцы почвы был выделен бактериальный штамм Arthrobacter sp. KM-Р, который был способен использовать...

The quinolones are an important group of synthetic antimicrobial drugs used for treating bacterial diseases of humans and animals. Microorganisms transform antimicrobial quinolones (including fluoroquinolones) and the pharmacologically related naphthyridones, pyranoacridones, and cinnolones to a...

The fungal and bacterial transformation of terpenoids derived from plant essential oils, especially the sesquiterpenoid artemisinin from Artemisia annua, has produced several new candidate drugs for the treatment of malaria. Obtaining new derivatives of terpenoids, including artemisinin...

Изучена микробная трансформация энрофлоксацина грибом Mucor ramannianus

Монография посвящена методам биотехнологии. В работе описаны примеры применения микробных технологий для получения производных противомалярийных лекарств из...

Pyridine, quinoline, acridine, indole, carbazole, and other heterocyclic nitrogen-containing compounds (azaarenes) can be transformed by cultures of bacteria and fungi to produce a variety of new derivatives, many of which have biological activity. In many cases, the microbial biotransformation...

Hydroxylation of the Multiple Bond in 1Benzyl-3-methyl-Δ3-piperideine by Micellar Fungi by Cunninghamella verticillata

Описана микробная трансформация 4-фенилпирролидина растущими культурами грибов.

This article describes the microbial conversion of the plant-derived antimalarial drug, artemisinin to 7β-hydroxyartemisinin, 4α-hydroxy-1-deoxoartemisinin, 6β-hydroxyartemisinin and 5β-hydroxyartemisinin, and the conversion of 10-deoxoartemisinin to 5β-hydroxy-10-deoxoartemisinin,...

The ability of a nonpathogenic fungus, Pestalotiopsis guepini, to metabolize fluoroquinolone antimicrobial agents during growth on poultry litter materials was investigated. Sterilized rice hulls, ground corncobs, and pine shavings in glass jars covered with foil were moistened with sterile water...

The ability of the fungus Beauveria bassiana ATCC 7159 to transform the antibacterial agent cinoxacin was investigated. Cultures in sucrose–peptone broth were dosed with cinoxacin, grown for 20 days, and then extracted with ethyl acetate. Two metabolites were detected and purified by...

The formation of conjugates from two antibacterial fluoroquinolone drugs, ciprofloxacin and norfloxacin, was observed in cultures of Trichoderma viride that had been grown in sucrose-peptone broth and extracted 16 d after dosing with the drugs. Both conjugates were purified by high-performance...

To investigate the microbial biotransformation of veterinary fluoroquinolones, Mucor ramannianus was grown in sucrose/peptone broth with sarafloxacin for 18 days. Cultures were extracted with ethyl acetate and extracts were analyzed by liquid chromatography. The two metabolites (26% and 15% of...

To determine the ability of fungi to metabolize sulphur- and oxygen-containing azaarenes, Cunninghamella elegans ATCC 9245 was grown in 125-ml flasks containing fluid Sabouraud medium. The cultures and controls were incubated at 28°C with shaking and dosed with 16.7 mM phenothiazine or...

Cultures of the fungi Aspergillus niger, Cunninghamella verticillata, and Penicillium simplicissimum, grown in a sucrose/peptone medium, transformed N-acetylphenothiazine to N-acetylphenothiazine sulfoxide (from 13% to 28% of the total) and phenothiazine sulfoxide (from 5% to 27%)....

A strain of the saprobic fungus Mucor ramannianus, isolated from a forest, was used to demonstrate the potential for ciprofloxacin biotransformation by zygomycetes in the environment. The fungus carried out the regioselective N-acetylation of ciprofloxacin to a single product, which was purified...

Изучены биопревращения 1-бензил-3-метилпипридина-3 мицелиальными грибами.

Микробиологическая трансформация производных мирценаля

Исследована биотрансформация аналога лекарственного препарата «Такрин» - 9-амино-1,2,3,4,5,6,7,8,-октагидроакридина грибом Cunninghamella verticillata ВКПМ F-430

Изучена трансформация аналога лекарственного препарата «Такрин» грибами.

We generalize literature data on transformation of aromatic and hydrogenated heterocycles. We show that in some cases, the processes have been accomplished regioselectively and stereoselectively in preparative yields.

Изучена микробная трансформация лекарства "Димебон"